The effect of oral administration of Withania somnifera root on formalin-induced pain in diabetic rats
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Abstract:
Abstract Introduction: Hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. With c onsidering the potential anti-diabetic effect of the medicinal plant Withania somnifera (WS)( ashwagandha), this study was designed to investigate the analgesic effect of WS on formalin-induced nociceptive responses (standard formalin test) in diabetic rats. Methods: Rats were divided into control, WS-treated control, diabetic, sodium salicylate (SS)-treated control and diabetic and WS-treated diabetic groups. For induction of diabetes, streptozotocin (STZ) was used at a single dose. The treatment groups received oral administration of ashwagandha -mixed rat pellet (6.25%) for two months. Results: The results showed that diabetic rats exhibited a higher score of pain at both phases of the formalin test and WS-treated diabetic rats exhibited a lower nociceptive score at both phases of the test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test in the diabetic group (p<0.01). Discussion: Taken together, these results indicate that two-month administration of ashwagandha could attenuate nociceptive score in an experimental model of diabetes mellitus and this may be considered as a potential treatment for painful diabetic neuropathy.
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15 صفحه اولThe Effect of Oral Administration of Withania Somnifera Root on Formalin-Induced Pain in Diabetic Rats
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the effect of oral administration of withania somnifera root on formalin-induced pain in diabetic rats
abstract introduction: hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of the patients. with c onsidering the potential anti-diabetic effect of the medicinal plant withania somnifera (ws)( ashwagandha), this study was designed to investigate the analgesic effect of ws on formalin-induced nociceptive responses (standard formali...
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The present investigation explores the possibilities of using the root and leaf extracts of an important plant Withania somnifera targeting DM and to examine their hypoglycaemic and hypolipidaemic effects on Streptozotocin-induced diabetic rats. Withania somnifera root extracts (WSREt) and leaf extracts (WSLEt) were orally administered daily to diabetic rats for eight weeks. After the treatment...
full textHypoglycaemic and Hypolipidaemic Effects of Withania somnifera Root and Leaf Extracts on Alloxan-Induced Diabetic Rats
Withania somnifera is an important medicinal plant, which is used in traditional medicine to cure many diseases. Flavonoids were determined in the extracts of W. somnifera root (WSREt) and leaf (WSLEt). The amounts of total flavonoids found in WSREt and WSLEt were 530 and 520 mg/100 g dry weight (DW), respectively. Hypoglycaemic and hypolipidaemic effects of WSREt and WSLEt were also investigat...
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15 صفحه اولMy Resources
Journal title
volume 1 issue 1
pages 29- 31
publication date 2009-01
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